Abstract: Hepatic encephalopathy (HE) is a serious neurological complication associated with liver dysfunction, characterized by cognitive impairment, altered consciousness, and neuromuscular disturbances. This case study investigates the presentation, diagnostic challenges, and therapeutic approaches in a Marwari mare diagnosed with HE. The mare presented with acute onset of behavioral changes, lethargy, and disorientation, prompting clinical evaluation and diagnostic tests revealing hepatic dysfunction. Treatment included dietary management, lactulose administration, and supportive care aimed at ammonia reduction and hepatic function restoration. Despite initial challenges, the mare responded positively to therapy, highlighting the importance of early recognition and targeted intervention in managing HE in equine patients, particularly those of unique breed backgrounds like the Marwari. Further research is warranted to refine diagnostic criteria and therapeutic strategies tailored to breed-specific susceptibilities.
