This study was conducted to evaluate the effect of different agro-climatic factors on various production, reproduction and growth traits of Hardhenu cattle. Effects of period and season of birth, period and season of calving, and parity on different targeted traits were analysed in 440 Hardhenu cows held at the Cattle breeding farm, Department of Animal Genetics and Breeding, Lala Lajpat Rai University of Veterinary and Animal Sciences, Hisar, Haryana. The overall least-squares means of Total Milk Yield (TMY), 300 days milk yield (300D MY), lactation length (LL), dry period (DP), service period (SP), calving interval (CI), number of AI per conception (AI/conception), birth weight, body weight at one month, two month and three month were 3854.47±181.79 kg, 3691.13±205.02 kg, 299.89±10.86 days, 89.12±13.64 days, 385.00±16.00 days, 104.50±15.71 days, 1.57±0.22, 24.88±0.54 kg, 32.96±0.85 kg, 41.08±1.06 kg and 60.94±1.54 kg, respectively. Among different agro-climatic factors, the period of birth had significant (p<0.05) effect on birth weight, one month body weight and two month body weight. Similarly, calving period (p<0.01) and parity (p<0.05) had significant effect on TMY, 300D MY, LL and DP. It was observed that winter season was found to be suitable for lesser AI/conception. It was concluded that proper managerial practices need to be followed for overall improvement in the targeted traits in Hardhenu cattle.