Author(s): Sonu, Hariom, Ajit Verma, Sweety, Vaibhav Bhardwaj and Gaurav Charaya

Abstract: Chronic kidney disease describes the gradual loss of kidney function and loss of the ability of kidneys to excrete waste products, concentrate urine, electrolytes and fluid balance leading to retention of creatinine, urea and other metabolic waste products. Routinely used biomarkers like serum creatinine and blood urea nitrogen (BUN) are not specific or sensitive in diagnosis disease. Therefore, the present study was planned to evaluate the correlation of Cystatin C with the severity of disease and with BUN & creatinine, respectively. The investigation was carried out on 24 clinical cases suspected of renal failure in dogs on the basis of clinical signs admitted at (VCC), Lala Lajpat Rai University of Veterinary and Animal Sciences (LUVAS), Hisar. All the dogs were divided into three categories based on the duration of presentation of cases after emergence of the clinical signs. Serum from affected animal and 6 apparently healthy animal was used to evaluate Cystatin C using ELISA kits whereas BUN and creatinine were calculated using biochemistry autoanalyzer. Correlation between Cystatin C with BUN and Creatinine was determined using correlation. Cystatin C were significantly elevated in dogs suffering from renal failure as compared to the control group. Among different category, in dogs showing atypical signs of renal failure significantly (<0.01) positive correlation between cystatin C with serum creatinine & BUN. Mild illness were showed significantly (<0.01). This can concluded that cystatin c as early diagnostic biomarker.

DOI: 10.33545/26174693.2024.v8.i3Se.767