Author(s): Sonali D Borkar, Manju Roy, Suresh G Jadhao, B Roopali and SK Singh

Abstract: This review delves into the groundbreaking CRISPR/Cas9 technology, showcasing its diverse applications in genome editing, gene therapy, drug discovery, disease modeling, and combatting antibiotic resistance. From addressing genetic disorders and infectious diseases to enhancing food security, CRISPR/Cas9 offers multifaceted solutions across fields like medicine and agriculture. In gene therapy, it shows potential in treating diseases such as sickle cell disease and cystic fibrosis through targeted gene modifications in clinical trials. In drug discovery, CRISPR/Cas9 expedites the identification of therapeutic targets and aids in developing novel treatments by precise genetic modifications in cells and animal models. Additionally, it presents innovative strategies for managing infectious diseases by combating antibiotic resistance and viral infections like HIV. In agriculture, CRISPR/Cas9 enables precise genome editing to enhance traits like disease resistance and yield, fostering improved productivity and sustainability. Despite these challenges, CRISPR/Cas9 emerges as a versatile tool with immense potential in addressing diverse health and agricultural and related issues.

DOI: 10.33545/26174693.2024.v8.i6e.1336