The anthracnose of chilli caused by Colletotrichum capsici (Syd.) is a wide spread problem limiting the profitable cultivation of chilli throughout the major chilli growing regions of India Present research was aimed to check the efficacy of various physical, botanicals, bio-agents and chemicals in vitro as well in vivo condition. Two botanicals viz., Garlic and Neem, two chemical fungicides such as captan and mancozeb and four combination treatments viz., Captan + Neem extract, Mancozeb + Garlic extract, Trichoderma harzianum + Captan and Pseudomonas fluorescens + Carbendazim were tested at different concentrations i.e. 50, 100, 200, 400 and 600 ppm and two biocontrol agents (T. harzianum and P. fluorescens) were observed for their antagonistic against C. capsici in vitro. Neem showed maximum inhibition at all concentration i.e. 38.96%, 40.99%, 50.00%, 55.17% and 57.20% respectively.