Author(s): Abdul Bari Hejran, Atiqullah Sarwari, Abdul Wahid Monib, Mohammad Hassan Hassand, Abdul Qadeer Baseer, Sayedwali Sediqi, Uzair Mohammad Kakar, Mustafa Rahime and Parwiz Niazi

Abstract: The influence of coronaviruses on the human gut microflora is a topic of emerging interest within the scientific community. Coronaviruses, particularly those like SARS-CoV-2, which causes COVID-19, are primarily known for respiratory symptoms but have broader impacts on human health. Recent research suggests that coronaviruses can affect the gut microflora, the diverse community of microorganisms inhabiting the gastrointestinal tract, which plays a crucial role in human health and disease. Studies indicate that coronaviruses may disrupt the gut microflora directly or indirectly. Direct effects could occur through viral invasion of intestinal cells expressing the ACE2 receptor, which is the cellular entry point for coronaviruses. Indirect effects may arise due to systemic inflammation triggered by the viral infection, affecting gut microbial composition and function. Dysbiosis, an imbalance in gut microbial communities, has been observed in COVID-19 patients, indicating potential coronavirus-mediated alterations. Understanding these interactions is vital because the gut microflora influences immune responses, nutrient metabolism, and overall well-being. Altered microbial profiles due to coronavirus infections might contribute to the prolonged gastrointestinal symptoms reported in COVID-19 patients. Moreover, changes in gut microflora composition could impact the efficacy of therapies and vaccines, given the role of the microflora in modulating immune system function. Future research should explore the mechanisms underlying coronavirus-mediated alterations in gut microflora and their implications for health outcomes. This includes investigating how viral infections influence specific microbial species and their metabolic activities. Longitudinal studies are needed to assess whether these changes persist beyond the acute phase of infection and how they correlate with clinical outcomes. In summary, coronaviruses can exert significant influences on the human gut microflora, potentially disrupting microbial communities and functions essential for health. This understanding could inform therapeutic strategies targeting gut microflora to improve outcomes in coronavirus-infected individuals and enhance our broader understanding of host-microflora interactions in infectious diseases.

DOI: 10.33545/26174693.2024.v8.i5a.1056